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Carvajal, Jorge A. The planned sample size (n=64) provided at least 86% power to detect a 40% absolute difference, or RR of 2.6, in the proportion of women achieving uterine quiescence. Evidence from human and animal studies indicates nitric oxide inhibits uterine contractility and may help maintain uterine quiescence during pregnancy. Arias-Montaño, José-Antonio Araya, Francisca Isabel Cuello, Mauricio A. Casanello, Paola C. Barragán-Ramírez, Guillermo Found 10 sentences matching phrase "quiescence".Found in 3 ms. Regulation of quiescence and contractility of the pregnant myometrium Preterm birth (6 births globally each year, is a major cause of death within the first month of postnatal life. View all Google Scholar citations Carvajal, Jorge A. Cuello, Mauricio A. Close this message to accept cookies or find out how to manage your cookie settings. quiescence . Vargas, Paula A. Feature Flags: { uterine quiescence and days to delivery. "isLogged": "0", This data will be updated every 24 hours. The regulation of uterine activity during pregnancy can be divided into four distinct physiologic phases : Phase 0: inhibitors active – Throughout most of pregnancy the uterus is maintained in a state of functional quiescence through the action of various putative inhibitors including, but not limited to: It requires not only the near absence of myometrial contractions, but also its refractoriness to contractile agents. Previously, we discovered that miR-200 family members serve as progesterone (P4)-modulated activators of contraction-associated genes in the pregnant uterus. During pregnancy, the uterine smooth muscle is quiescent. The length of mammalian pregnancy is tightly regulated to assure the delivery of a newborn mature enough to survive the extra-uterine environment. Poblete, José A. "openAccess": "0", In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. 2006. "openAccess": "0", English In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence . Cells may exit the cell cycle at G 1 and enter a nonproliferative phase called G 0 or quiescence. "figures": false, Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. At the molecular level, an integrated uterine endoplasmic reticulum stress-unfolded protein response (UPR-ERSR) regulates both caspase-3 (CASP3) and caspase-7 (CASP7), preserving myometrial quiescence throughout gestation. What explains the quiescence of uterine smooth muscle during gestation? Published online by Cambridge University Press:  This data will be updated every 24 hours. for this article. "shouldUseHypothesis": true, } During pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) activity, but labor is facilitated by a series of events that impair PR function. Using the mouse as our model system, we examined, … and Synonym Discussion of quiescent. Query parameters: { Myometrial smooth muscle contractions are phasic in nature and are driven by action potentials. "newCiteModal": false "shouldUseShareProductTool": true, relative uterine quiescence during continuing pregnancy to the initiation of uterine contractions at the onset of labour. Soloff MS(1), Jeng YJ, Izban MG, Sinha M, Luxon BA, Stamnes SJ, England SK. translation and definition "quiescence", English-Greek Dictionary online. Santiago, Chile. We use cookies to distinguish you from other users and to provide you with a better experience on our websites. and Adequate uterine contractility is involved in the transport of the semen and gametes and in successful embryo implantation, whereas inadequate uterine contractility may lead to ectopic pregnancies, miscarriages, retrograde bleeding and endometriosis (Leyendecker et al., 2004; Bulletti and de Ziegler, 2005; Kissler et al., 2005). In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. "shouldUseShareProductTool": true, for this article. Address for correspondence: Jorge A Carvajal, Marcoleta 391, Centro de Investigaciones Médicas, Pontificia Universidad Católica de Chile, Santiago, Chile. "isUnsiloEnabled": true, Fernández-Martínez, Eduardo Context sentences for "quiescence" in Polish These sentences come from external sources and may not be accurate. In this situation, measurement of cervical length during quiescence and during a uterine contraction is useful for differentiating a normal latent phase from dysfunctional active labor. "newCiteModal": false Poblete, Jose A. } Whether a decrease in plasma progesterone is the essential prerequisite for the initiation of parturition or whether other factors also maintain uterine quiescence until delivery is not known. Experimental Physiology (2001) 86.2, 265-272. : The early Cretaceous is characterized by relative quiescence and thermal subsidence following late Jurassic rifting. Quiescence search, in game tree searching (adversarial search) in artificial intelligence, a quiescent state is one in which a game is considered stable and unlikely to change drastically the next few plays Seed dormancy, a form of delayed seed germination Quiescent phase, … Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland. Weiner, Carl P. Learn more. Additional filters were used downstream of clustering for genes related to uterine quiescence and term activation. Total loading time: 0.195 Ponce-Monter, Héctor If you should have access and can't see this content please. Published online by Cambridge University Press:  The planned sample size (n=64) provided at least 86% power to detect a 40% absolute difference, or RR of 2.6, in the proportion of women achieving uterine quiescence. As a result, forceful uterine contractions do not occur until the ninth month of pregnancy. "lang": "en" 2016. A successful pregnancy requires near complete relaxation of the uterus for more than ninety-five percent of gestation, overcoming the inherent tendency of the myometrium to contract with stretch. and At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. "figures": false, Vidal, Rossana J. During pregnancy, the uterine smooth muscle is quiescent. Rapture was self-transcending, which led … labor are unique. Delpiano, Ana María 2019 Jan;39:520-530. doi: 10.1016/j.ebiom.2018.11.038. A. Oxytocin inhibits contraction of uterine smooth muscle Close this message to accept cookies or find out how to manage your cookie settings. Additional filters were used downstream of clustering for genes related to uterine quiescence and term activation. Poblete, José A. Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and have a … * Views captured on Cambridge Core between September 2016 - 24th January 2021. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. * Views captured on Cambridge Core between September 2016 - 22nd January 2021. For clusters related to quiescence and term activation, a change of more than 20% was required for the midgestation (14.5 days) and term (18.5 days) time points, respectively, versus non-pregnant controls. 2. These include the possibility of electrophysiological changes in myometrial cells. The periodical return of the symptoms after a shorter or longer period of quiescence. and Delpiano, Ana M. Poblete, Jose A. "isLogged": "0", PARTURITION is defined as the process of bringing forth of young which comprises of multiple transformations in both uterine and cervical functions There are four phases : Quiescence The regulation of uterine activity during pregnancy can be divided into four distinct physiologic phases : Phase 0: inhibitors active – Throughout most of pregnancy the uterus is maintained in a state of functional quiescence through the action of various putative inhibitors including, but not limited to: In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence. The causes of preterm labor are not well understood, so progesterone action on the myometrium can provide clues about the processes that … Showing page 1. "shouldUseHypothesis": true, bab.la is not responsible for their content. Weiner, Carl P. In fertile women, directed unilateral transport of immotile sperm-like material through the genital tract to the side bearing the dominant follicle can be assessed using hysterosalping… Delpiano, Ana M. A.Le retour périodique des symptômes après un intervalle plus ou moins long de tranquillité. Using the mouse as our model system, we examined, by Western blot analysis, levels of active caspase 3 and its association with the degradation of uterine contractile proteins during pregnancy. This active and highly regulated process is called myometrial quiescence. These findings illustrate the diversity of potential cAMP generating pathways in human myometrium, and the complexity of the signal transduction systems underlying uterine quiescence. In contrast, UC frequency remained elevated (at 60% end-follicular phase values) until 4 days after hCG and declined thereafter (6 days after hCG). "isUnsiloEnabled": true, School of Medicine, Pontificia Universidad Católica de Chile. View all Google Scholar citations uterine quiescence and days to delivery. Evidence from human and animal studies indicates nitric oxide inhibits uterine contractility and may help maintain uterine quiescence during pregnancy. It is accepted that whilst hormones such as oxytocin, vasopressin and prostaglandin F2α induce myometrial contractions, essentially via an elevation of intracellular calcium, other ligands, such as β-adrenoceptor agonists, calcitonin gene-related peptide, and prostaglandin E2, promote uterine quiescence via their ability to increase intracellular cyclic AMP levels. Carvajal, Jorge A. The first phase is quiescence and represents that time in utero before labor begins when uterine activity is suppressed by the action of progesterone, prostacyclin, relaxin, nitric oxide, 2013. Get access to the full version of this content by using one of the access options below. If you should have access and can't see this content please. We have verified the presence of mRNA encoding adenylyl cyclase (AC) isoforms I, II, III, V, VI, VII, VIII and IX in both non-pregnant and pregnant human myometrium, and in isolated myometrial cells maintained in cell culture. Hostname: page-component-76cb886bbf-pdn9z }. : The next four decades saw periods of resurgence and quiescence in Soviet anti-Semitism. The }, Uterine quiescence: the role of cyclic AMP, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. Mayén-García, Cynthia Quiescence (/kwiˈɛsəns/) is a state of quietness or inactivity. In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. For clusters related to quiescence and term activation, a change of more than 20% was required for the midgestation (14.5 days) and term (18.5 days) time points, respectively, versus non-pregnant controls. What explains the quiescence of uterine smooth muscle during gestation? In this study, we identified a unique role for miR … PARTURITION is defined as the process of bringing forth of young which comprises of multiple transformations in both uterine and cervical functions There are four phases : Quiescence This active and highly regulated process is called myometrial quiescence. and The uterus (from Latin "uterus", plural uteri) or womb (/ w uː m /) is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.In the human, the lower end of the uterus, the cervix, opens into the vagina, while the upper end, the fundus, is connected to the fallopian tubes.It is within the uterus that the fetus develops during gestation. Furthermore, by means of immunoblotting and immunocytochemistry, we have demonstrated the expression of these isoforms as membrane-associated AC proteins, and identified changes in individual AC isoform expression during gestation. As a result, forceful uterine contractions do not occur until the ninth month of pregnancy. We use cookies to distinguish you from other users and to provide you with a better experience on our websites. translation and definition "quiescence", English-Greek Dictionary online. The appropriate timing of the onset of labor is critical to a successful pregnancy, with potentially devastating consequences resulting to both the mother and child with the onset of preterm labor. In the menstrual cycle, a prompt decrease in UC frequency was observed. The four phases of labor from quiescence to involution are outlined in Figure 13-1. https://doi.org/10.1017/S0965539503001098. Ferrer, Fernando Andrés 16 October 2003. Sobrevia, Luis A. Whilst many studies have aimed to understand the mechanisms underlying uterine contractility there is a relative paucity of data regarding myometrial relaxation. Render date: 2021-01-22T15:18:36.920Z Carvajal, Jorge Andrés At the molecular level, an integrated uterine endoplasmic reticulum stress-unfolded protein response (UPR-ERSR) regulates both caspase-3 (CASP3) and caspase-7 (CASP7), preserving myometrial quiescence throughout gestation. MECHANISMS UNDERLYING MYOMETRIAL QUIESCENCE DURING... Department of Obstetrics and Gynecology; Maternal-Fetal Research Laboratory. The safety and analysis populations were defined as all … quiescence translation in English-Swedish dictionary. Inactive, resting, silent Medtalk A period during which an infection is present but not active in a host Examples TB; chickenpox and recrudescence as herpes zoster–shingles. "metricsAbstractViews": false, msoloff @ … Bethune was a man of peace, one who wanted stability and who in the interests … uterine definition: 1. relating to the uterus: 2. relating to the uterus: 3. of or relating to the uterus: . "hasAccess": "0", In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence. The highest rates of preterm birth (≥15% of all live births) occur in sub-Saharan Africa, Pakistan and Indonesia. and Did You Know? "hasAccess": "0", Epub 2018 Nov 28. 31 July 2001. Delpiano, Ana M. The maintenance of uterine quiescence across gestation is fundamental for term parturition. 2013. 2017. Using the mouse as our model system, we examined, by Western blot analysis, levels of active caspase 3 and its association with the degradation of uterine contractile proteins during pregnancy. Get access to the full version of this content by using one of the access options below. Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy EBioMedicine. 2009. How to use quiescent in a sentence. Cuello, Mauricio A. Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. Feature Flags: { Total loading time: 1.54 Carvajal, Jorge A. Author information: (1)Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA. Should have access and ca n't see this content please regulation of active uterine caspase 3 regulation... Quiescent definition is - marked uterine quiescence meaning inactivity or repose: tranquilly at rest from other users and to provide with... De uterine quiescence meaning ; Maternal-Fetal Research Laboratory the uterine smooth muscle is quiescent may exit the cycle... 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